Epitopes in α8β1 and other RGD-binding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits

Identification of epitopes for integrin-blocking monoclonal antibodies (mAbs) has aided our understanding of structure-function relationship of integrins. We mapped epitopes of chicken anti-integrin-α8-subunit-blocking mAbs by mutational analyses, examining regions that harboured all mapped epitopes...

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Detalles Bibliográficos
Autores principales: Nishimichi, Norihisa, Kawashima, Nagako, Yokosaki, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563375/
https://www.ncbi.nlm.nih.gov/pubmed/26349930
http://dx.doi.org/10.1038/srep13756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563375/
https://www.ncbi.nlm.nih.gov/pubmed/26349930
http://dx.doi.org/10.1038/srep13756

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