Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors

Human epidermal growth factor receptor (EGFR) is an important drug target that plays a fundamental role in signal transduction pathways in oncology. We report herein the discovery of a novel class of phenylpiperazine derivatives with improved potency toward EGFR. The biological activity of compound...

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Detalles Bibliográficos
Autores principales: Sun, Juan, Wang, Xin-Yi, Lv, Peng-Cheng, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563558/
https://www.ncbi.nlm.nih.gov/pubmed/26349898
http://dx.doi.org/10.1038/srep13934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563558/
https://www.ncbi.nlm.nih.gov/pubmed/26349898
http://dx.doi.org/10.1038/srep13934

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