A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesir...

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Detalles Bibliográficos
Autores principales: Smith, Mark E. B., Caspersen, Mikael B., Robinson, Eifion, Morais, Maurício, Maruani, Antoine, Nunes, João P. M., Nicholls, Karl, Saxton, Malcolm J., Caddick, Stephen, Baker, James R., Chudasama, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563668/
https://www.ncbi.nlm.nih.gov/pubmed/26108475
http://dx.doi.org/10.1039/c5ob01205h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563668/
https://www.ncbi.nlm.nih.gov/pubmed/26108475
http://dx.doi.org/10.1039/c5ob01205h

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