Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) directly interacts with the small-conductance Ca(2+)-activated K(+) 2-a (SK2-a) channel/calmodulin complex, serving as a critical element in the regulation of channel activity. We report that changes of protein conformation in close proximity to the PIP...

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Detalles Bibliográficos
Autores principales: Zhang, Miao, Meng, Xuan-Yu, Zhang, Ji-fang, Cui, Meng, Logothetis, Diomedes E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563807/
https://www.ncbi.nlm.nih.gov/pubmed/26366439
http://dx.doi.org/10.1126/sciadv.1500008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563807/
https://www.ncbi.nlm.nih.gov/pubmed/26366439
http://dx.doi.org/10.1126/sciadv.1500008

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