Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells

Small molecule inhibitors against protein geranylgeranyltransferase-I such as P61A6 have been shown to inhibit proliferation of a variety of human cancer cells and exhibit antitumor activity in mouse models. Development of these inhibitors could be dramatically accelerated by conferring tumor target...

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Detalles Bibliográficos
Autores principales: Lu, Jie, Yoshimura, Kohei, Goto, Koichi, Lee, Craig, Hamura, Ken, Kwon, Ohyun, Tamanoi, Fuyuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564137/
https://www.ncbi.nlm.nih.gov/pubmed/26352258
http://dx.doi.org/10.1371/journal.pone.0137595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564137/
https://www.ncbi.nlm.nih.gov/pubmed/26352258
http://dx.doi.org/10.1371/journal.pone.0137595

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