Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension

Tumour Necrosis Factor-α (TNF-α) inhibition has been transformational in the treatment of patients with inflammatory disease, e.g. rheumatoid arthritis. Intriguingly, TNF-α signals through two receptors, TNFR1 and TNFR2, which have been associated with detrimental inflammatory and beneficial immune-...

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Detalles Bibliográficos
Autores principales: Goodall, Laura J., Ovecka, Milan, Rycroft, Daniel, Friel, Sarah L., Sanderson, Andrew, Mistry, Prafull, Davies, Marie L., Stoop, A. Allart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564187/
https://www.ncbi.nlm.nih.gov/pubmed/26352810
http://dx.doi.org/10.1371/journal.pone.0137065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564187/
https://www.ncbi.nlm.nih.gov/pubmed/26352810
http://dx.doi.org/10.1371/journal.pone.0137065

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