DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy, and genetic instability. This study profiles DNA methylation in SCLC, patient-derived xenografts (PDXs) and cell lines at single nucleotide resolution. DNA me...

Descripción completa

Detalles Bibliográficos
Autores principales: Poirier, John T., Gardner, Eric E., Connis, Nick, Moreira, Andre L., de Stanchina, Elisa, Hann, Christine L., Rudin, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564363/
https://www.ncbi.nlm.nih.gov/pubmed/25746006
http://dx.doi.org/10.1038/onc.2015.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564363/
https://www.ncbi.nlm.nih.gov/pubmed/25746006
http://dx.doi.org/10.1038/onc.2015.38

Ejemplares similares