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Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells

Tumor cells generate extracellular superoxide anions and are protected against intercellular apoptosis-inducing HOCl- and NO/peroxynitrite signaling through the expression of membrane-associated catalase. This enzyme decomposes H(2)O(2) and thus prevents HOCl synthesis. It efficiently interferes wit...

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Detalles Bibliográficos
Autor principal: Bauer, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564397/
https://www.ncbi.nlm.nih.gov/pubmed/26342455
http://dx.doi.org/10.1016/j.redox.2015.07.017