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Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells
Tumor cells generate extracellular superoxide anions and are protected against intercellular apoptosis-inducing HOCl- and NO/peroxynitrite signaling through the expression of membrane-associated catalase. This enzyme decomposes H(2)O(2) and thus prevents HOCl synthesis. It efficiently interferes wit...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564397/ https://www.ncbi.nlm.nih.gov/pubmed/26342455 http://dx.doi.org/10.1016/j.redox.2015.07.017 |