Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling

MuSK antibody-positive myasthenia gravis (MuSK-MG) accounts for 5 to 15% of autoimmune MG. MuSK and LRP4 are coreceptors for agrin in the signaling pathway that causes clustering of acetylcholine receptor (AChR). MuSK also anchors the acetylcholinesterase (AChE)/collagen Q (ColQ) complex to the syna...

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Detalles Bibliográficos
Autores principales: Otsuka, Kenji, Ito, Mikako, Ohkawara, Bisei, Masuda, Akio, Kawakami, Yu, Sahashi, Ko, Nishida, Hiroshi, Mabuchi, Naoki, Takano, Akemi, Engel, Andrew G., Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564764/
https://www.ncbi.nlm.nih.gov/pubmed/26355076
http://dx.doi.org/10.1038/srep13928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564764/
https://www.ncbi.nlm.nih.gov/pubmed/26355076
http://dx.doi.org/10.1038/srep13928

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