Cargando…

Structural Dynamics and Thermostabilization of Neurotensin Receptor 1

[Image: see text] The neurotensin receptor NTSR1 binds the peptide agonist neurotensin (NTS) and signals preferentially via the G(q) protein. Recently, Grisshammer and co-workers reported the crystal structure of a thermostable mutant NTSR1-GW5 with NTS bound. Understanding how the mutations thermos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sangbae, Bhattacharya, Supriyo, Tate, Christopher G., Grisshammer, Reinhard, Vaidehi, Nagarajan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564841/ https://www.ncbi.nlm.nih.gov/pubmed/25807267 http://dx.doi.org/10.1021/jp510735f

Ejemplares similares

Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors
por: Bhattacharya, Supriyo, et al.
Publicado: (2014)

Structure and dynamics of a constitutively active neurotensin receptor
por: Krumm, Brian E., et al.
Publicado: (2016)

Dynamic Behavior of the Active and Inactive States of the Adenosine A(2A) Receptor
por: Lee, Sangbae, et al.
Publicado: (2014)

Thermostabilisation of the neurotensin receptor NTS1
por: Shibata, Yoko, et al.
Publicado: (2009)

Structure of the agonist-bound neurotensin receptor
por: White, Jim F., et al.
Publicado: (2012)

Structural prerequisites for G-protein activation by the neurotensin receptor
por: Krumm, Brian E., et al.
Publicado: (2015)

Stability of the Neurotensin Receptor NTS1 Free in Detergent Solution and Immobilized to Affinity Resin
por: White, Jim F., et al.
Publicado: (2010)

Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A(2A) Receptor
por: Lee, Sangbae, et al.
Publicado: (2019)

Transient and Stable Expression of the Neurotensin Receptor NTS1: A Comparison of the Baculovirus-Insect Cell and the T-REx-293 Expression Systems
por: Xiao, Su, et al.
Publicado: (2013)

How Do Branched Detergents Stabilize GPCRs in Micelles?
por: Lee, Sangbae, et al.
Publicado: (2020)

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
por: Inagaki, Sayaka, et al.
Publicado: (2015)

THE THERMOSTABILE ANTICOMPLEMENTARY CONSTITUENTS OF THE BLOOD
por: Noguchi, Hideyo
Publicado: (1906)

ON CERTAIN THERMOSTABILE VENOM ACTIVATORS
por: Noguchi, Hideyo
Publicado: (1906)

Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1
por: Huang, Weijiao, et al.
Publicado: (2020)

Computational design of thermostabilizing point mutations for G protein-coupled receptors
por: Popov, Petr, et al.
Publicado: (2018)

Using Mutability Landscapes To Guide Enzyme Thermostabilization
por: Guo, Chao, et al.
Publicado: (2020)

Imaging Neurotensin Receptor in Prostate Cancer With (64)Cu-Labeled Neurotensin Analogs
por: Deng, Huaifu, et al.
Publicado: (2017)

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation
por: Green, Evan M., et al.
Publicado: (2015)

A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties
por: Lee, Hee-Kyoung, et al.
Publicado: (2015)

A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors
por: Amer, Marwa, et al.
Publicado: (2023)

Structure-Based Evolution of Subtype-Selective Neurotensin Receptor Ligands
por: Schaab, Carolin, et al.
Publicado: (2014)

Neurotensin receptors in pancreatic ductal carcinomas
por: Körner, Meike, et al.
Publicado: (2015)

Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor
por: Suno, Ryoji, et al.
Publicado: (2018)

Endogenous CNS Expression of Neurotensin and Neurotensin Receptors Is Altered during the Postpartum Period in Outbred Mice
por: Driessen, Terri M., et al.
Publicado: (2014)

A Dynamic Hydrophobic Core and Surface Salt Bridges Thermostabilize a Designed Three-Helix Bundle
por: Nguyen, Catrina, et al.
Publicado: (2019)

Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin
por: Rouibi, Khalil, et al.
Publicado: (2015)

Design, Synthesis, and Biological Evaluation of the First Radio-Metalated Neurotensin Analogue Targeting Neurotensin Receptor 2
por: Bodin, Sacha, et al.
Publicado: (2023)

Application of Rigidity Theory to the Thermostabilization of Lipase A from Bacillus subtilis
por: Rathi, Prakash Chandra, et al.
Publicado: (2016)

Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release
por: Tzeng, Stephany Y., et al.
Publicado: (2016)

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
por: Coleman, Jonathan A., et al.
Publicado: (2016)

Thermostabilization of the uronate dehydrogenase from Agrobacterium tumefaciens by semi-rational design
por: Roth, Teresa, et al.
Publicado: (2017)

Thermostabilization mechanisms in thermophilic versus mesophilic three‐helix bundle proteins
por: Nguyen, Catrina, et al.
Publicado: (2021)

Accurate Prediction of Enzyme Thermostabilization with Rosetta Using AlphaFold Ensembles
por: Peccati, Francesca, et al.
Publicado: (2023)

Neurotensin and its receptors in the control of glucose homeostasis
por: Mazella, Jean, et al.
Publicado: (2012)

Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body
por: Porzionato, A., et al.
Publicado: (2009)

Cannabinoid CB(1) Receptors Mediate the Gastroprotective Effect of Neurotensin
por: Hassanzadeh, Parichehr, et al.
Publicado: (2012)

Neurotensin receptor 1 signaling promotes pancreatic cancer progression
por: Takahashi, Kei, et al.
Publicado: (2020)

Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility
por: Futamata, Haon, et al.
Publicado: (2022)

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin
por: Law, Ivy Ka Man, et al.
Publicado: (2016)

Validation of Neurotensin Receptor 1 as a Therapeutic Target for Gastric Cancer
por: Akter, Hafeza, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8dcdfkr90h1dkq6q8p5ui8su4o