Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. They are among the most highly pursued drug targets, with relevance for several neurological diseases, and a number of allosteric modulators have entered clinical trials. However, so far thi...

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Detalles Bibliográficos
Autores principales: Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G., Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H., Bräuner-Osborne, Hans, Gloriam, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566082/
https://www.ncbi.nlm.nih.gov/pubmed/26359761
http://dx.doi.org/10.1038/srep13869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566082/
https://www.ncbi.nlm.nih.gov/pubmed/26359761
http://dx.doi.org/10.1038/srep13869

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