Cargando…

Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment

Mathematical modelling has been instrumental to understand kinetics of radiation-induced DNA damage repair and associated secondary cancer risk. The widely accepted two-lesion kinetic (TLK) model assumes two kinds of double strand breaks, simple and complex ones, with different repair rates. Recentl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rastgou Talemi, Soheil, Kollarovic, Gabriel, Lapytsko, Anastasiya, Schaber, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566481/ https://www.ncbi.nlm.nih.gov/pubmed/26359627 http://dx.doi.org/10.1038/srep13540

Ejemplares similares

To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage
por: Kollarovic, Gabriel, et al.
Publicado: (2016)

FoCo: a simple and robust quantification algorithm of nuclear foci
por: Lapytsko, Anastasiya, et al.
Publicado: (2015)

Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks
por: Schaber, Jörg, et al.
Publicado: (2014)

Systems Level Analysis of the Yeast Osmo-Stat
por: Talemi, Soheil Rastgou, et al.
Publicado: (2016)

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

BRCA1 in the DNA damage response and at telomeres
por: Rosen, Eliot M.
Publicado: (2013)

The telomere protein tankyrase 1 regulates DNA damage responses at telomeres
por: Chang, Sandy
Publicado: (2010)

The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function
por: Doksani, Ylli
Publicado: (2019)

Photo-induced telomeric DNA damage in human cancer cells
por: Weynand, Justin, et al.
Publicado: (2022)

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
por: Hewitt, Graeme, et al.
Publicado: (2012)

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
por: Nakamura, Asako J, et al.
Publicado: (2008)

Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
por: Nakamura, Asako J., et al.
Publicado: (2009)

Telomeric Recombination Induced by DNA Damage Results in Telomere Extension and Length Heterogeneity
por: Liu, Haiying, et al.
Publicado: (2018)

Oxidative Stress Induces Persistent Telomeric DNA Damage Responsible for Nuclear Morphology Change in Mammalian Cells
por: Coluzzi, Elisa, et al.
Publicado: (2014)

DNA damage signalling prevents deleterious telomere addition at DNA breaks
por: Makovets, Svetlana, et al.
Publicado: (2009)

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
por: Rossiello, Francesca, et al.
Publicado: (2014)

Inhibition of the DNA Damage Pathway by a Telomere-Binding Protein
Publicado: (2004)

Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways
por: Oikemus, Sarah R, et al.
Publicado: (2006)

Taming the tiger by the tail: modulation of DNA damage responses by telomeres
por: Lydall, David
Publicado: (2009)

The telomeric DNA damage response occurs in the absence of chromatin decompaction
por: Vancevska, Aleksandra, et al.
Publicado: (2017)

Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma
por: Yu, Eun Young, et al.
Publicado: (2019)

Telomere length dynamics in response to DNA damage in malaria parasites
por: Reed, Jake, et al.
Publicado: (2021)

Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
por: Maciejewska, Natalia, et al.
Publicado: (2022)

Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis
por: Usategui, Alicia, et al.
Publicado: (2022)

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
por: Passos, João F., et al.
Publicado: (2007)

Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair
por: Rochette, Patrick J., et al.
Publicado: (2010)

Polymerase η suppresses telomere defects induced by DNA damaging agents
por: Pope-Varsalona, Hannah, et al.
Publicado: (2014)

SNM1B/Apollo in the DNA damage response and telomere maintenance
por: Schmiester, Maren, et al.
Publicado: (2017)

DNA- and telomere-damage does not limit lifespan: evidence from rapamycin
por: Blagosklonny, Mikhail V.
Publicado: (2021)

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response
por: Imran, Siti A. M., et al.
Publicado: (2021)

Telomere damage induces internal loops that generate telomeric circles
por: Mazzucco, Giulia, et al.
Publicado: (2020)

The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response
por: Cicconi, Alessandro, et al.
Publicado: (2017)

The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients
por: Aljarbou, Ftoon, et al.
Publicado: (2018)

How time delay and network design shape response patterns in biochemical negative feedback systems
por: Börsch, Anastasiya, et al.
Publicado: (2016)

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2
por: Opresko, Patricia L., et al.
Publicado: (2005)

A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest
por: Hayashi, Makoto T., et al.
Publicado: (2012)

Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells
por: Gurung, Resham Lal, et al.
Publicado: (2010)

Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death
por: Sun, Luxi, et al.
Publicado: (2015)

Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast
por: Holstein, Eva-Maria, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_08903coo7ripc0vi1qnqj1hv90