Japanese encephalitis virus replicon-based vaccine expressing enterovirus-71 epitope confers dual protection from lethal challenges

BACKGROUND: To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutralizing epitope SP70 derived from enterovirus-71 (EV71). Such pseudo-infectious...

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Detalles Bibliográficos
Autores principales: Huang, Yi-Ting, Liao, Jia-Teh, Yen, Li-Chen, Chang, Yung-Kun, Lin, Yi-Ling, Liao, Ching-Len
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566489/
https://www.ncbi.nlm.nih.gov/pubmed/26362772
http://dx.doi.org/10.1186/s12929-015-0181-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566489/
https://www.ncbi.nlm.nih.gov/pubmed/26362772
http://dx.doi.org/10.1186/s12929-015-0181-8

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