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Japanese encephalitis virus replicon-based vaccine expressing enterovirus-71 epitope confers dual protection from lethal challenges
BACKGROUND: To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutralizing epitope SP70 derived from enterovirus-71 (EV71). Such pseudo-infectious...
Autores principales: | Huang, Yi-Ting, Liao, Jia-Teh, Yen, Li-Chen, Chang, Yung-Kun, Lin, Yi-Ling, Liao, Ching-Len |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566489/ https://www.ncbi.nlm.nih.gov/pubmed/26362772 http://dx.doi.org/10.1186/s12929-015-0181-8 |
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