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Blockade of CD82 by a monoclonal antibody potentiates anti-leukemia effects of AraC in vivo

We recently found that CD82 inhibits matrix metalloproteinase 9 and augments adhesion of CD34(+)/CD38(−) acute myelogenous leukemia (AML) cells to the bone marrow (BM) microenvironment. The present study found that the use of an anti-CD82 monoclonal antibody (CD82 mAb) mobilized CD34(+) leukemia cel...

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Detalles Bibliográficos
Autores principales: Nishioka, Chie, Ikezoe, Takayuki, Yokoyama, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567027/
https://www.ncbi.nlm.nih.gov/pubmed/26139471
http://dx.doi.org/10.1002/cam4.482