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Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling

Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses retain this experimental search space, as model definitions typically rely on...

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Detalles Bibliográficos
Autores principales: Flobak, Åsmund, Baudot, Anaïs, Remy, Elisabeth, Thommesen, Liv, Thieffry, Denis, Kuiper, Martin, Lægreid, Astrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567168/
https://www.ncbi.nlm.nih.gov/pubmed/26317215
http://dx.doi.org/10.1371/journal.pcbi.1004426