Phosphoflow-Based Evaluation of Mek Inhibitors as Small-Molecule Therapeutics for B-Cell Precursor Acute Lymphoblastic Leukemia

Upstream mutations that lead to constitutive activation of Erk in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are relatively common. In the era of personalized medicine, flow cytometry could be used as a rapid method for selection of optimal therapies, which may include drugs that target...

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Detalles Bibliográficos
Autores principales: George, Aswathi A., Paz, Helicia, Fei, Fei, Kirzner, Jonathan, Kim, Yong-mi, Heisterkamp, Nora, Abdel-Azim, Hisham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567297/
https://www.ncbi.nlm.nih.gov/pubmed/26360058
http://dx.doi.org/10.1371/journal.pone.0137917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567297/
https://www.ncbi.nlm.nih.gov/pubmed/26360058
http://dx.doi.org/10.1371/journal.pone.0137917

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