Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape....

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Detalles Bibliográficos
Autores principales: Nichol, Daniel, Jeavons, Peter, Fletcher, Alexander G., Bonomo, Robert A., Maini, Philip K., Paul, Jerome L., Gatenby, Robert A., Anderson, Alexander R.A., Scott, Jacob G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567305/
https://www.ncbi.nlm.nih.gov/pubmed/26360300
http://dx.doi.org/10.1371/journal.pcbi.1004493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567305/
https://www.ncbi.nlm.nih.gov/pubmed/26360300
http://dx.doi.org/10.1371/journal.pcbi.1004493

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