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Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape....
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567305/ https://www.ncbi.nlm.nih.gov/pubmed/26360300 http://dx.doi.org/10.1371/journal.pcbi.1004493 |