PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment

BACKGROUND: The PD-1 axis is a cell intrinsic immunoregulatory pathway that mediates T cell exhaustion in chronic infection particularly in some viral infections. We hypothesized that PD-1, PD-L1 and PD-L2 would be highly expressed in untreated tuberculosis patients compared to controls due to their...

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Detalles Bibliográficos
Autores principales: Hassan, Syeda S., Akram, Muhammad, King, Elizabeth C., Dockrell, Hazel M., Cliff, Jacqueline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567315/
https://www.ncbi.nlm.nih.gov/pubmed/26359860
http://dx.doi.org/10.1371/journal.pone.0137646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567315/
https://www.ncbi.nlm.nih.gov/pubmed/26359860
http://dx.doi.org/10.1371/journal.pone.0137646

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