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High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder with pathological features including death of dopaminergic neurons in the substantia nigra and intraneuronal accumulations of Lewy bodies. As the main component of Lewy bodies, α-synuclein is implicated in PD pathogenesis by aggregat...

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Detalles Bibliográficos
Autores principales: Kong, Yan, Liang, Xijun, Liu, Lin, Zhang, Dongdong, Wan, Chao, Gan, Zhenji, Yuan, Liudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567341/
https://www.ncbi.nlm.nih.gov/pubmed/26361355
http://dx.doi.org/10.1371/journal.pone.0137432