A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

APC, a key negative regulator of Wnt signaling in development and oncogenesis, acts in the destruction complex with the scaffold Axin and the kinases GSK3 and CK1 to target βcatenin for destruction. Despite 20 years of research, APC's mechanistic function remains mysterious. We used FRAP, super...

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Detalles Bibliográficos
Autores principales: Pronobis, Mira I, Rusan, Nasser M, Peifer, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568445/
https://www.ncbi.nlm.nih.gov/pubmed/26393419
http://dx.doi.org/10.7554/eLife.08022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568445/
https://www.ncbi.nlm.nih.gov/pubmed/26393419
http://dx.doi.org/10.7554/eLife.08022

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