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Direct production of XY(DMY−) sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs
Medaka is an ideal model for sex determination and sex reversal, such as XY phenotypically female patients in humans. Here, we assembled improved TALENs targeting the DMY gene and generated XY(DMY−) mutants to investigate gonadal dysgenesis in medaka. DMY-TALENs resulted in indel mutations at the ta...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568496/ https://www.ncbi.nlm.nih.gov/pubmed/26365677 http://dx.doi.org/10.1038/srep14057 |