Direct production of XY(DMY−) sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs

Medaka is an ideal model for sex determination and sex reversal, such as XY phenotypically female patients in humans. Here, we assembled improved TALENs targeting the DMY gene and generated XY(DMY−) mutants to investigate gonadal dysgenesis in medaka. DMY-TALENs resulted in indel mutations at the ta...

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Detalles Bibliográficos
Autores principales: Luo, Daji, Liu, Yun, Chen, Ji, Xia, Xiaoqin, Cao, Mengxi, Cheng, Bin, Wang, Xuejuan, Gong, Wuming, Qiu, Chao, Zhang, Yunsheng, Ki Cheng, Christopher Hon, Zhu, Zuoyan, Hu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568496/
https://www.ncbi.nlm.nih.gov/pubmed/26365677
http://dx.doi.org/10.1038/srep14057

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