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Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling

The Hv1 voltage-gated proton channel is a dimeric complex consisting of two voltage-sensing domains (VSDs), each containing a gated proton permeation pathway. Dimerization is controlled by a cytoplasmic coiled-coil domain. The transitions from the closed to the open state in the two VSDs are known t...

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Detalles Bibliográficos
Autores principales: Hong, Liang, Singh, Vikrant, Wulff, Heike, Tombola, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568520/
https://www.ncbi.nlm.nih.gov/pubmed/26365828
http://dx.doi.org/10.1038/srep14077