Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

TP53 is the most frequently mutated gene among all human cancers. Prevalent p53 missense mutations abrogate its tumor suppressive function and lead to “gain-of-function” (GOF) that promotes cancer. Here we show that p53 GOF mutants bind to and upregulate chromatin regulatory genes, including the met...

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Detalles Bibliográficos
Autores principales: Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568559/
https://www.ncbi.nlm.nih.gov/pubmed/26331536
http://dx.doi.org/10.1038/nature15251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568559/
https://www.ncbi.nlm.nih.gov/pubmed/26331536
http://dx.doi.org/10.1038/nature15251

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