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Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma

During inflammation, high-mobility group box 1 in reduced all-thiol form (at-HMGB1) takes charge of chemoattractant activity, whereas only disulfide-HMGB1 (ds-HMGB1) has cytokine activity. Also as pro-angiogenic inducer, the role of HMGB1 in different redox states has never been defined in tumour an...

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Detalles Bibliográficos
Autores principales: Zhu, Lingyin, Ren, Lin, Chen, Yingxuan, Fang, Jingyuan, Ge, Zhizheng, Li, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568917/
https://www.ncbi.nlm.nih.gov/pubmed/26099505
http://dx.doi.org/10.1111/jcmm.12577