Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

Atorvastatin, fluvastatin and rosuvastatin are drugs used for treatment of hypercholesterolemia. They cause numerous drug-drug interactions by inhibiting and inducing drug-metabolizing cytochromes P450. These three statins exist in four optical forms, but they are currently used as enantiopure drugs...

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Detalles Bibliográficos
Autores principales: Korhonova, Martina, Doricakova, Aneta, Dvorak, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569258/
https://www.ncbi.nlm.nih.gov/pubmed/26366873
http://dx.doi.org/10.1371/journal.pone.0137720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569258/
https://www.ncbi.nlm.nih.gov/pubmed/26366873
http://dx.doi.org/10.1371/journal.pone.0137720

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