Cargando…
A Rescue Strategy for Handling Unevaluable Patients in Simon’s Two Stage Design
For phase II oncology trials, Simon’s two-stage design is the most commonly used strategy. However, when clinically unevaluable patients occur, the total number of patients included at each stage differs from what was initially planned. Such situations raise concerns about the operating characterist...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569274/ https://www.ncbi.nlm.nih.gov/pubmed/26368810 http://dx.doi.org/10.1371/journal.pone.0137586 |