Cargando…
Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia
Fungal infections have skyrocketed in immune-compromised patients lacking CD4(+) T cells, underscoring the need for vaccine prevention. An understanding of the elements that promote vaccine immunity in this setting is essential. We previously demonstrated that vaccine-induced IL-17A(+) CD8(+) T cell...
Autores principales: | Nanjappa, Som Gowda, Hernández-Santos, Nydiaris, Galles, Kevin, Wüthrich, Marcel, Suresh, M., Klein, Bruce S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569330/ https://www.ncbi.nlm.nih.gov/pubmed/26367276 http://dx.doi.org/10.1371/journal.ppat.1005161 |
Ejemplares similares
-
Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells
por: Nanjappa, Som Gowda, et al.
Publicado: (2017) -
Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4(+) T Cells
por: Nanjappa, Som Gowda, et al.
Publicado: (2012) -
MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4(+) T Cells during the Contraction Phase
por: Wang, Huafeng, et al.
Publicado: (2016) -
Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
por: Li, Qian, et al.
Publicado: (2021) -
MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)