Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation

OBJECTIVE: 5-Fluorouracil (5-Fu) has been widely used as a first-line drug for colorectal cancer (CRC) treatment but limited by drug resistance and severe toxicity. The chemo-sensitizers that augment its efficiency and overcome its limitation are urgently needed. Gypenosides (Gyp), the main componen...

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Detalles Bibliográficos
Autores principales: Kong, Lulu, Wang, Xiaobing, Zhang, Kun, Yuan, Wenjuan, Yang, Qiwen, Fan, Jianping, Wang, Pan, Liu, Quanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569363/
https://www.ncbi.nlm.nih.gov/pubmed/26368019
http://dx.doi.org/10.1371/journal.pone.0137888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569363/
https://www.ncbi.nlm.nih.gov/pubmed/26368019
http://dx.doi.org/10.1371/journal.pone.0137888

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