Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation

CD4(+) T-helper cells that produce interleukin-17 (Th17 cells) are characterized as pathological T-helper cells in autoimmune diseases. Differentiation of human and mouse Th17 cells requires a key transcription regulator, retinoic acid receptor-related orphan receptor γt (RORγt), which is a potentia...

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Detalles Bibliográficos
Autores principales: Ding, Qingfeng, Zhao, Mei, Yu, Bolan, Bai, Chuan, Huang, Zhaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569406/
https://www.ncbi.nlm.nih.gov/pubmed/26368822
http://dx.doi.org/10.1371/journal.pone.0137711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569406/
https://www.ncbi.nlm.nih.gov/pubmed/26368822
http://dx.doi.org/10.1371/journal.pone.0137711

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