Cargando…
Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation
CD4(+) T-helper cells that produce interleukin-17 (Th17 cells) are characterized as pathological T-helper cells in autoimmune diseases. Differentiation of human and mouse Th17 cells requires a key transcription regulator, retinoic acid receptor-related orphan receptor γt (RORγt), which is a potentia...
Autores principales: | Ding, Qingfeng, Zhao, Mei, Yu, Bolan, Bai, Chuan, Huang, Zhaofeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569406/ https://www.ncbi.nlm.nih.gov/pubmed/26368822 http://dx.doi.org/10.1371/journal.pone.0137711 |
Ejemplares similares
-
Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds
por: Ding, Qingfeng, et al.
Publicado: (2015) -
The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis
por: Ruan, Qingguo, et al.
Publicado: (2011) -
RORγt and RORα signature genes in human Th17 cells
por: Castro, Glenda, et al.
Publicado: (2017) -
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo
por: Guendisch, Ulf, et al.
Publicado: (2017) -
Two amino acid mutation disrupts RORγt function in Th17 differentiation but not thymocyte development
por: He, Zhiheng, et al.
Publicado: (2017)