Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase

Gamma-secretase-mediated Notch3 signaling is involved in smooth muscle cell (SMC) hyper-activity and proliferation leading to pulmonary arterial hypertension (PAH). In addition, Propylthiouracil (PTU), beyond its anti-thyroid action, has suppressive effects on atherosclerosis and PAH. Here, we inves...

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Detalles Bibliográficos
Autores principales: Lai, Ying-Ju, Chang, Gwo-Jyh, Yeh, Yung-Hsin, Pang, Jong-Hwei S., Huang, Chung-Chi, Chen, Wei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569419/
https://www.ncbi.nlm.nih.gov/pubmed/26367462
http://dx.doi.org/10.1371/journal.pone.0137426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569419/
https://www.ncbi.nlm.nih.gov/pubmed/26367462
http://dx.doi.org/10.1371/journal.pone.0137426

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