Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack

The opportunistic human pathogen Pseudomonas aeruginosa controls host innate immune and complement attack. Here we identify Dihydrolipoamide dehydrogenase (Lpd), a 57 kDa moonlighting protein, as the first P. aeruginosa protein that binds the two human terminal pathway inhibitors vitronectin and clu...

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Detalles Bibliográficos
Autores principales: Hallström, Teresia, Uhde, Melanie, Singh, Birendra, Skerka, Christine, Riesbeck, Kristian, Zipfel, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569481/
https://www.ncbi.nlm.nih.gov/pubmed/26368530
http://dx.doi.org/10.1371/journal.pone.0137630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569481/
https://www.ncbi.nlm.nih.gov/pubmed/26368530
http://dx.doi.org/10.1371/journal.pone.0137630

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