Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp

Cyclic GMP (cGMP) signalling regulates multiple biological functions through activation of protein kinase G and cyclic nucleotide-gated (CNG) channels. In sensory neurons, cGMP permits signal modulation, amplification and encoding, before depolarization. Here we implement a guanylyl cyclase rhodopsi...

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Detalles Bibliográficos
Autores principales: Gao, Shiqiang, Nagpal, Jatin, Schneider, Martin W., Kozjak-Pavlovic, Vera, Nagel, Georg, Gottschalk, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569695/
https://www.ncbi.nlm.nih.gov/pubmed/26345128
http://dx.doi.org/10.1038/ncomms9046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569695/
https://www.ncbi.nlm.nih.gov/pubmed/26345128
http://dx.doi.org/10.1038/ncomms9046

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