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Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds
Humans are chronically exposed to multiple exogenous substances, including environmental pollutants, drugs and dietary components. Many of these compounds are suspected to impact human health, and their combination in complex mixtures could exacerbate their harmful effects. Here we demonstrate that...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569708/ https://www.ncbi.nlm.nih.gov/pubmed/26333997 http://dx.doi.org/10.1038/ncomms9089 |