BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization

We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF(3)·Et(2)O catalyzed reaction was found to be selective for product formation w...

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Detalles Bibliográficos
Autores principales: Srivastava, Ambika, Singh, Pooja, Kumar, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569759/
https://www.ncbi.nlm.nih.gov/pubmed/26421007
http://dx.doi.org/10.1155/2015/527159
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author Srivastava, Ambika
Singh, Pooja
Kumar, Rajesh
author_facet Srivastava, Ambika
Singh, Pooja
Kumar, Rajesh
author_sort Srivastava, Ambika
collection PubMed
description We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF(3)·Et(2)O catalyzed reaction was found to be selective for product formation while anhydrous AlCl(3), FeCl(3), and SnCl(4) catalyzed ones were nonselective.
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spelling pubmed-45697592015-09-29 BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization Srivastava, Ambika Singh, Pooja Kumar, Rajesh Adv Pharmacol Sci Research Article We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF(3)·Et(2)O catalyzed reaction was found to be selective for product formation while anhydrous AlCl(3), FeCl(3), and SnCl(4) catalyzed ones were nonselective. Hindawi Publishing Corporation 2015 2015-09-01 /pmc/articles/PMC4569759/ /pubmed/26421007 http://dx.doi.org/10.1155/2015/527159 Text en Copyright © 2015 Ambika Srivastava et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Srivastava, Ambika
Singh, Pooja
Kumar, Rajesh
BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization
title BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization
title_full BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization
title_fullStr BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization
title_full_unstemmed BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization
title_short BF(3)·Et(2)O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization
title_sort bf(3)·et(2)o catalysed 4-aryl-3-phenyl-benzopyrones, pro-serms, and their characterization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569759/
https://www.ncbi.nlm.nih.gov/pubmed/26421007
http://dx.doi.org/10.1155/2015/527159
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