Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

Alterations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the most common pediatric brain tumor. Although inhibitors targeting the membrane protein Smoothened suppress Hh signaling, acquired drug resistance and tumor relapse call for additional therapeutic t...

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Detalles Bibliográficos
Autores principales: Ge, Xuecai, Milenkovic, Ljiljana, Suyama, Kaye, Hartl, Tom, Purzner, Teresa, Winans, Amy, Meyer, Tobias, Scott, Matthew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569902/
https://www.ncbi.nlm.nih.gov/pubmed/26371509
http://dx.doi.org/10.7554/eLife.07068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569902/
https://www.ncbi.nlm.nih.gov/pubmed/26371509
http://dx.doi.org/10.7554/eLife.07068

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