O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-α and mice with collagen induced arthritis

INTRODUCTION: We investigated the inflammatory potential of O-linked N-acetylglucosamine glycosylation (O-GlcNAcylation) of p65 in rheumatoid arthritis (RA). METHODS: Fibroblast-like synoviocytes (FLS) and MH7A cells were treated with synthetic ThiaMet-G (200 μM), an O-GlcNAcase (OGA) inhibitor, fol...

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Detalles Bibliográficos
Autores principales: Kim, Han Byeol, Lee, Sang Won, Mun, Chin Hee, Yoon, Ji Young, Pai, Jaeyoung, Shin, Injae, Park, Yong Beom, Lee, Soo Kon, Cho, Jin Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570085/
https://www.ncbi.nlm.nih.gov/pubmed/26370562
http://dx.doi.org/10.1186/s13075-015-0762-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570085/
https://www.ncbi.nlm.nih.gov/pubmed/26370562
http://dx.doi.org/10.1186/s13075-015-0762-7

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