How to outsmart NK cell tolerance

Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cel...

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Detalles Bibliográficos
Autores principales: Terszowski, Grzegorz, Klein, Christian, Schmied, Laurent, Stern, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570122/
https://www.ncbi.nlm.nih.gov/pubmed/26405590
http://dx.doi.org/10.1080/2162402X.2015.1016708
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author Terszowski, Grzegorz
Klein, Christian
Schmied, Laurent
Stern, Martin
author_facet Terszowski, Grzegorz
Klein, Christian
Schmied, Laurent
Stern, Martin
author_sort Terszowski, Grzegorz
collection PubMed
description Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cell tolerance.
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spelling pubmed-45701222016-02-03 How to outsmart NK cell tolerance Terszowski, Grzegorz Klein, Christian Schmied, Laurent Stern, Martin Oncoimmunology Author's View Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cell tolerance. Taylor & Francis 2015-04-02 /pmc/articles/PMC4570122/ /pubmed/26405590 http://dx.doi.org/10.1080/2162402X.2015.1016708 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Terszowski, Grzegorz
Klein, Christian
Schmied, Laurent
Stern, Martin
How to outsmart NK cell tolerance
title How to outsmart NK cell tolerance
title_full How to outsmart NK cell tolerance
title_fullStr How to outsmart NK cell tolerance
title_full_unstemmed How to outsmart NK cell tolerance
title_short How to outsmart NK cell tolerance
title_sort how to outsmart nk cell tolerance
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570122/
https://www.ncbi.nlm.nih.gov/pubmed/26405590
http://dx.doi.org/10.1080/2162402X.2015.1016708
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