The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

Gastric hormone ghrelin regulates insulin secretion, as well as growth hormone release, feeding behavior and adiposity. Ghrelin is known to exert its biological actions by interacting with the growth hormone secretagogue-receptor (GHSR) coupled to G(q/11)-protein signaling. By contrast, ghrelin acts...

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Detalles Bibliográficos
Autores principales: Kurashina, Tomoyuki, Dezaki, Katsuya, Yoshida, Masashi, Sukma Rita, Rauza, Ito, Kiyonori, Taguchi, Masanobu, Miura, Rina, Tominaga, Makoto, Ishibashi, Shun, Kakei, Masafumi, Yada, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570196/
https://www.ncbi.nlm.nih.gov/pubmed/26370322
http://dx.doi.org/10.1038/srep14041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570196/
https://www.ncbi.nlm.nih.gov/pubmed/26370322
http://dx.doi.org/10.1038/srep14041

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