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L(59) TGF-β LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice
BACKGROUND: Hepatic fibrosis, which is the excessive accumulation of extracellular matrices (ECMs) produced mainly from activated hepatic stellate cells (HSCs), develops to cirrhosis over several decades. There are no validated biomarkers that can non-invasively monitor excessive production of ECM (...
Autores principales: | Hara, Mitsuko, Inoue, Ikuyo, Yamazaki, Yuta, Kirita, Akiko, Matsuura, Tomokazu, Friedman, Scott L., Rifkin, Daniel B., Kojima, Soichi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570586/ https://www.ncbi.nlm.nih.gov/pubmed/26379781 http://dx.doi.org/10.1186/s13069-015-0034-9 |
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