Cargando…

Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis

RATIONALE: Pulmonary fibrosis is a progressive disease with only few treatment options available at the moment. Recently, the nucleoside uridine has been shown to exert anti-inflammatory effects in different animal models, e.g. in acute lung injury or bronchial asthma. METHOD: Therefore, we investig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cicko, Sanja, Grimm, Melanie, Ayata, Korcan, Beckert, Jessica, Meyer, Anja, Hossfeld, Madelon, Zissel, Gernot, Idzko, Marco, Müller, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570657/ https://www.ncbi.nlm.nih.gov/pubmed/26369416 http://dx.doi.org/10.1186/s12931-015-0264-9

Ejemplares similares

Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI)
por: Cicko, Sanja, et al.
Publicado: (2018)

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation
por: Zech, Andreas, et al.
Publicado: (2016)

The purinergic receptor subtype P2Y(2) mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease
por: Müller, Tobias, et al.
Publicado: (2017)

P2Y(6) Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis
por: Müller, Tobias, et al.
Publicado: (2017)

Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP
por: Scherr, Benedikt F., et al.
Publicado: (2023)

P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis
por: Rennert, Laura, et al.
Publicado: (2018)

Gamma Linolenic Acid Exerts Anti-Inflammatory and Anti-Fibrotic Effects in Diabetic Nephropathy
por: Kim, Do-Hee, et al.
Publicado: (2012)

CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells
por: Kuhny, Marcel, et al.
Publicado: (2014)

Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo
por: Khan, Petra, et al.
Publicado: (2022)

AMP Affects Intracellular Ca(2+) Signaling, Migration, Cytokine Secretion and T Cell Priming Capacity of Dendritic Cells
por: Panther, Elisabeth, et al.
Publicado: (2012)

Oxymatrine exerts anti-fibrotic effects in a rat model of hepatic fibrosis by suppressing endoplasmic reticulum stress
por: Liu, Xiaodong, et al.
Publicado: (2020)

Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33
por: Calvén, Jenny, et al.
Publicado: (2015)

Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung
por: Lucattelli, Monica, et al.
Publicado: (2016)

5-Hydroxytryptamine Modulates Migration, Cytokine and Chemokine Release and T-Cell Priming Capacity of Dendritic Cells In Vitro and In Vivo
por: Müller, Tobias, et al.
Publicado: (2009)

Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
por: Wang, Huafeng, et al.
Publicado: (2016)

Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants: Supplementing Perfusion Solutions With Anti-fibrotic Drugs
por: van Leeuwen, L. Leonie, et al.
Publicado: (2022)

Novel Anti-fibrotic Therapies
por: McVicker, Benita L., et al.
Publicado: (2017)

Corrigendum: Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
por: Wang, Huafeng, et al.
Publicado: (2016)

Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis
por: Yu, Qian, et al.
Publicado: (2023)

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells
por: Blanchard, Olivier, et al.
Publicado: (2018)

Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars
por: Vanderstichele, Sophie, et al.
Publicado: (2022)

Microvascular Targets for Anti-Fibrotic Therapeutics
por: Pu, Kai-Ming T., et al.
Publicado: (2013)

Role of purinergic signaling in experimental pneumococcal meningitis
por: Zierhut, Marco, et al.
Publicado: (2017)

Palladium-catalyzed C–H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues
por: Zhao, Qin, et al.
Publicado: (2022)

Anti-Hepatitis C Virus Activity of Uridine Derivatives of 2-Deoxy Sugars
por: Krol, Ewelina, et al.
Publicado: (2018)

Fibrotic microtissue array to predict anti-fibrosis drug efficacy
por: Asmani, Mohammadnabi, et al.
Publicado: (2018)

Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis
por: Costalonga, Elerson C., et al.
Publicado: (2017)

Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy
por: Zhang, Zequn, et al.
Publicado: (2021)

Inhibition of miR-155-5p Exerts Anti-Fibrotic Effects in Silicotic Mice by Regulating Meprin α
por: Chen, Yingying, et al.
Publicado: (2019)

Anti-fibrotic potential of erythropoietin signaling on bone marrow derived fibrotic cell
por: Iwata, Yasunori, et al.
Publicado: (2021)

Anti-fibrotic Potential of AT(2) Receptor Agonists
por: Wang, Yan, et al.
Publicado: (2017)

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics
por: Dolivo, David, et al.
Publicado: (2021)

Anti-Fibrotic Effects of RF Electric Currents
por: Hernández-Bule, María Luisa, et al.
Publicado: (2023)

Disease progression in idiopathic pulmonary fibrosis under anti-fibrotic treatment
por: Cilli, Aykut, et al.
Publicado: (2023)

The Anti-Fibrotic Effect of Cold Atmospheric Plasma on Localized Scleroderma In Vitro and In Vivo
por: Arndt, Stephanie, et al.
Publicado: (2021)

The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice
por: Wang, Yan, et al.
Publicado: (2022)

Indispensable residue for uridine binding in the uridine-cytidine kinase family
por: Tomoike, Fumiaki, et al.
Publicado: (2017)

Anti-Fibrotic and Anti-Inflammatory Role of NO-Sensitive Guanylyl Cyclase in Murine Lung
por: Englert, Nils, et al.
Publicado: (2023)

Extracellular Vesicles Are More Potent Than Adipose Mesenchymal Stromal Cells to Exert an Anti-Fibrotic Effect in an In Vitro Model of Systemic Sclerosis
por: Rozier, Pauline, et al.
Publicado: (2021)

Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action
por: Karatzas, Evangelos, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8nv1k0qfn7bcmf1uq6geu1636r