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A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

Increasing evidence is emerging that immunotherapeutic interventions, including checkpoint blockade, are predominantly effective in patients with a pre-existing T cell-inflamed tumor microenvironment. Understanding the mechanisms leading to a non-T cell-inflamed microenvironment are crucial for the...

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Detalles Bibliográficos
Autores principales: Spranger, Stefani, Gajewski, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570721/
https://www.ncbi.nlm.nih.gov/pubmed/26380088
http://dx.doi.org/10.1186/s40425-015-0089-6