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Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics

We provide evidence to show that the standard reactant concentrations used in tissue engineering to cross-link collagen-based scaffolds are up to 100 times higher than required for mechanical integrity in service, and stability against degradation in an aqueous environment. We demonstrate this with...

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Detalles Bibliográficos
Autores principales: Davidenko, N., Schuster, C.F., Bax, D.V., Raynal, N., Farndale, R.W., Best, S.M., Cameron, R.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570933/
https://www.ncbi.nlm.nih.gov/pubmed/26213371
http://dx.doi.org/10.1016/j.actbio.2015.07.034