An efficient and safe process for the preparation of ticagrelor, a platelet aggregation inhibitor via resin-NO(2) catalyzed formation of triazole ring

An efficient, safe and improved process for the preparation of ticagrelor 1, a platelet aggregation inhibitor is described. Synthesis comprises the condensation of pyrimidine amine derivative 14 with cyclopentyl derivative 13 in ethylene glycol followed by construction of triazole compound 16 by dia...

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Detalles Bibliográficos
Autores principales: Shinde, Gorakshanath B., Mahale, Pravin K., Padaki, Santhosh A., Niphade, Navnath C., Toche, Raghunath B., Mathad, Vijayavitthal T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571033/
https://www.ncbi.nlm.nih.gov/pubmed/26389018
http://dx.doi.org/10.1186/s40064-015-1299-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571033/
https://www.ncbi.nlm.nih.gov/pubmed/26389018
http://dx.doi.org/10.1186/s40064-015-1299-6

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