An efficient and safe process for the preparation of ticagrelor, a platelet aggregation inhibitor via resin-NO(2) catalyzed formation of triazole ring

An efficient, safe and improved process for the preparation of ticagrelor 1, a platelet aggregation inhibitor is described. Synthesis comprises the condensation of pyrimidine amine derivative 14 with cyclopentyl derivative 13 in ethylene glycol followed by construction of triazole compound 16 by dia...

Descripción completa

Detalles Bibliográficos
Autores principales: Shinde, Gorakshanath B., Mahale, Pravin K., Padaki, Santhosh A., Niphade, Navnath C., Toche, Raghunath B., Mathad, Vijayavitthal T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571033/
https://www.ncbi.nlm.nih.gov/pubmed/26389018
http://dx.doi.org/10.1186/s40064-015-1299-6

Ejemplares similares

Ejemplares similares