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Crystal structure of (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman
The title compound, C(11)H(11)FO(2), is a building block in the synthesis of the active pharmaceutical ingredient dl-nebivolol. The synthesis starting from the enantiomerically pure (R)-6-fluoro-4-oxo-3,4-dihydro-2H-chromene-2-carboxylic acid resulted in a mixture of two stereoisomers, namely (R...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571392/ https://www.ncbi.nlm.nih.gov/pubmed/26396792 http://dx.doi.org/10.1107/S205698901501261X |